![]() LS Mean Change From Baseline in Normal-Luminance Best-Corrected Visual Acuity (NL-BCVA) Score of the Study Eye at Month 24.Baseline was defined as the last available, non-missing observation prior to first study drug administration. LS mean was calculated using a MMRM model. ![]() A negative change from baseline indicated a decrease in the FRI disease worsening. Mean FRI Index scores ranged from 1 (unable to do independently) to 4 (totally independent), with higher scores indicating higher functional reading independence. For each FRI Index reading activity performed in the past 7 days, subjects were asked about the extent to which they required assistance beyond eyeglasses/contact lenses, including the use of low-vision aids, adjustments in the activity, or help from another subject. The FRI was an interviewer-administered questionnaire with 7 items on functional reading activities most relevant to GA AMD subjects. LS Mean Change From Baseline in Monocular Maximum Reading Speed of the Study Eye at Month 24.The microperimetry reading center overlaid the baseline FAF images with GA lesions traced by the imaging reading center and the corresponding macular integrity assessment microperimetry baseline scanning laser ophthalmoscope image and identified perilesional (within 500 microns outside the atrophy border), paralesional (beyond 500 microns outside the atrophy border), and extralesional (outside the atrophy border) loci on the microperimetry grid to determine the mean threshold sensitivity for these 3 areas. Microperimetry offers the option to test retinal light sensitivity while directly observing the fundus and allows for monitoring of macular function loss associated with GA progression. Mean threshold sensitivity of all points was determined from the mesopic microperimetry as an assessment of the macular functional response. Why Should I Register and Submit Results?.
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